Critical guidelines for validation of the selectivity of in-vivo chemical microsensors
نویسندگان
چکیده
Microsensors are miniaturized analytical devices for making in-situ chemical measurements in biological systems with extraordinary temporal resolution. Their most severe limitation is chemical selectivity. Here, we suggest guidelines that can be applied to a range of in-vivo microsensor applications for evaluation of analyte identification and improvement of selectivity. # 2003 Published by Elsevier B.V.
منابع مشابه
Permeability and selectivity prediction of poly (4-methyl 1-pentane) membrane modified by nanoparticles in gas separation through artificial intelligent systems
In this work, the effects of operative parameters on CH4, CO2, O2, and N2 membrane gas separation for poly (4-methyl-1-pentane) (PMP) membrane modified by adding nanoparticles of TiO2, ZnO, and Al2O3 are assessed and investigated. The operative parameters were type and percentage of nanoparticles, and cross membrane pr...
متن کاملMethanol crossover and selectivity of nafion/heteropolyacid/montmorillonite nanocomposite proton exchange membranes for DMFC applications
In this work, we prepared the nafion/montmorillonite/heteropolyacid nanocomposite membranes for direct methanol fuel cells (DMFCs). The analyses such as X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM) were conducted to characterize the filler dispersion and membrane structure in prepared nanocomposite membranes. XRD patterns of nafion-CsPW-MMT ...
متن کاملRapid Analysis of Glibenclamide Using an Environmentally Benign Stability-Indicating RP-HPLC Method
An environmentally benign RP-HPLC approach for rapid analysis of glibenclamide in pure form, developed nanoemulsion and commercial tablets was developed and validated in present investigation. The green chromatographic identification was performed on Lichrosphere 250 X 4.0 mm RP C8 column having a 5µm packing as a stationary phase using a combination of ethanol: methanol (50:50 % v/v) as a mobi...
متن کاملRapid Analysis of Glibenclamide Using an Environmentally Benign Stability-Indicating RP-HPLC Method
An environmentally benign RP-HPLC approach for rapid analysis of glibenclamide in pure form, developed nanoemulsion and commercial tablets was developed and validated in present investigation. The green chromatographic identification was performed on Lichrosphere 250 X 4.0 mm RP C8 column having a 5µm packing as a stationary phase using a combination of ethanol: methanol (50:50 % v/v) as a mobi...
متن کاملPharmacophore Based Virtual Screening Approach to Identify Selective PDE4B Inhibitors
Phosphodiesterase 4 (PDE4) has been established as a promising target in asthma andchronic obstructive pulmonary disease. PDE4B subtype selective inhibitors are known toreduce the dose limiting adverse effect associated with non-selective PDE4B inhibitors. Thismakes the development of PDE4B subtype selective inhibitors a desirable research goal. Toachieve this goal, ligand based pharmacophore m...
متن کامل